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Both genera can competitively bind free iron in the gut to lower local iron ion concentrations, while simultaneously lowering intestinal pH through the formation of essential amino acids or SCFAs, thereby diminishing iron-dependent lipid peroxidation reactions (185)

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Consistent with this finding, we observed less respiration in response to CI and III substrates in isolated gWAT mitochondria and primary adipocytes from mice lacking adipocyte Ndufs2 (Extended Data Fig